This is an amazing card for those scenarios that feature lots of locations with nasty (travel) effects. Don't make the mistake I did in thinking it's a one-off effect: the player stays in control of the card when it's attached to a location (see also section 1.38 of the FAQ). That means that you can decide to use it's Response again at a later time, for example, after having travelled to a location and skipped its effect. The only restriction is the availability of other locations (and the proper use of the Action Windows).
Indeed, this key opens many doors!